Wednesday, February 26, 2014

GERMANY REPORTS ANOTHER CASE OF ATYPICAL BSE (H-TYPE)

Bovine spongiform encephalopathy,
Germany
 
Information received on 25/02/2014 from Dr. Karin Schwabenbauer, Ministerial Dirigentin and Chief Veterinary Officer , Directorate of Animal Health, Animal Welfare, Bundesministerium für Ernährung, Landwirtschaft und Verbraucherschutz (BMELV) , Bonn, Germany
Summary
Report type Immediate notification (Final report)
Date of start of the event 30/01/2014
Date of pre-confirmation of the event 04/02/2014
Report date 25/02/2014
Date submitted to OIE 25/02/2014
Date event resolved 13/02/2014
Reason for notification Reoccurrence of a listed disease
Date of previous occurrence 16/01/2014
Manifestation of disease Sub-clinical infection
Causal agent Prion (atypical BSE H-type)
Nature of diagnosis Laboratory (advanced)
This event pertains to the whole country
New outbreaks (1)
Outbreak 1 Prädikow, Prötzel, Märkisch-Oderland, BRANDENBURG
Date of start of the outbreak 30/01/2014
Outbreak status Resolved (13/02/2014)
Epidemiological unit Farm
Affected animals
Species Susceptible Cases Deaths Destroyed Slaughtered
Cattle 714 1 0 1 0
Summary of outbreaks Total outbreaks: 1
Total animals affected
Species Susceptible Cases Deaths Destroyed Slaughtered
Cattle 714 1 0 1 0
Outbreak statistics
Species Apparent morbidity rate Apparent mortality rate Apparent case fatality rate Proportion susceptible animals lost*
Cattle 0.14% 0.00% 0.00% 0.14%
*Removed from the susceptible population through death, destruction and/or slaughter
Epidemiology
Source of the outbreak(s) or origin of infection
  • Unknown or inconclusive
Epidemiological comments As part of the German targeted bovine spongiform encephalopathy (BSE) surveillance system, a BSE-case classified as atypical (H-type) was identified in a cow at slaughter. An epidemiological investigation of the event was conducted. The summary of the event is as follows: - The cow was slaughtered on 30.01.2014 at the age of eleven years and four months without clinical signs. - Results from the immuno blot tests at the NRL (Friedrich Loeffler-Institute) confirmed the animal positive for atypical BSE of the H-type, a very rare form of the disease not associated with feeding. - The animal´s carcass has been destroyed. The identified animal did not enter the food channels; at no time it presented any risk to human health. - The epidemiological investigation identified eight offspring cattle, three of which were already slaughtered, one of which has been fallen and four of which have been traded to another Member State. The tracing of the bovines born on the farm from one year before until one year after the birth of the identified cow revealed 371 bovines (177 have been already slaughtered, 63 were fallen stock, 3 have been traded within the territory of Germany, 127 have been traded to other States, one has been culled and destroyed). The OIE does not recognize an atypical form of BSE as a distinct entity for the purpose of its international standards; it is not mentioned in the OIE Terrestrial Animal Health Code, which does not distinguish between different forms of BSE.
Control measures
Measures applied
  • Movement control inside the country
  • Screening
  • Disinfection of infected premises/establishment(s)
  • Modified stamping out
  • No vaccination
  • No treatment of affected animals
Measures to be applied
  • No other measures
Diagnostic test results
Laboratory name and type Species Test Test date Result
Friedrich Loeffler-Institute (National laboratory) Cattle western blot 04/02/2014 Positive
Future Reporting
The event is resolved. No more reports will be submitted.
Map of outbreak locations
 

 

 

 

 

Saturday, January 18, 2014

 

GERMANY DETECTS A CASE OF ATYPICAL BSE Jan 17, 2014

 


 

 Saturday, January 18, 2014

 

Bovine spongiform encephalopathy ,Germany Information received on 17/01/2014

 


 

 

Thursday, February 14, 2013

 

Unique Properties of the Classical Bovine Spongiform Encephalopathy Strain and Its Emergence From H-Type Bovine Spongiform Encephalopathy Substantiated by VM Transmission Studies

 


 

Saturday, December 15, 2012

 

*** Bovine spongiform encephalopathy: the effect of oral exposure dose on attack rate and incubation period in cattle -- an update 5 December 2012

 


 

Saturday, August 14, 2010

 

***BSE Case Associated with Prion Protein Gene Mutation (g-h-BSEalabama) and VPSPr PRIONPATHY

 

*** (see mad cow feed in COMMERCE IN ALABAMA...TSS)

 


 

However, a BSE expert said that consumption of infected material is the only known way that cattle get the disease under natural conditons.

 

***“In view of what we know about BSE after almost 20 years experience, contaminated feed has been the source of the epidemic,” said Paul Brown, a scientist retired from the National Institute of Neurological Diseases and Stroke.

 

BSE is not caused by a microbe. It is caused by the misfolding of the so-called “prion protein” that is a normal constituent of brain and other tissues. If a diseased version of the protein enters the brain somehow, it can slowly cause all the normal versions to become misfolded. It is possible the disease could arise spontaneously, though such an event has never been recorded, Brown said.

 


 

*** What irks many scientists is the USDA’s April 25 statement that the rare disease is “not generally associated with an animal consuming infected feed.”

 

The USDA’s conclusion is a “gross oversimplification,” said Dr. Paul Brown, one of the world’s experts on this type of disease who retired recently from the National Institutes of Health. "(The agency) has no foundation on which to base that statement.”

 


 

Wednesday, February 12, 2014

 

*** USDA/APHIS NOTICE: Final Rule Regarding Imports and BSE Effective March 4, 2014

 


 

 Thursday, February 20, 2014

 

Unnecessary precautions BSE MAD COW DISEASE Dr. William James FSIS VS Dr. Linda Detwiler 2014

 


 

I ask Professor Kong ; Thursday, December 04, 2008 3:37 PM

 

Subject: RE: re--Chronic Wating Disease (CWD) and Bovine Spongiform Encephalopathies (BSE): Public Health Risk Assessment ''IS the h-BSE more virulent than typical BSE as well, or the same as cBSE, or less virulent than cBSE? just curious.....'' Professor Kong reply ;

 

.....snip

 

''As to the H-BSE, we do not have sufficient data to say one way or another, but we have found that H-BSE can infect humans. I hope we could publish these data once the study is complete. Thanks for your interest.''

 

Best regards, Qingzhong Kong, PhD Associate Professor Department of Pathology Case Western Reserve University Cleveland, OH 44106 USA END...TSS

 

Thursday, December 04, 2008 2:37 PM

 

"we have found that H-BSE can infect humans."

 

personal communication with Professor Kong. ...TSS

 

BSE-H is also transmissible in our humanized Tg mice. The possibility of more than two atypical BSE strains will be discussed.

 

Supported by NINDS NS052319, NIA AG14359, and NIH AI 77774.

 


 


 

please see below from PRION2013 ;

 

*** This study imply the possibility that the novel BSE prions with high virulence in cattle will be emerged during intraspecies transmission.

 

AD.56: The emergence of novel BSE prions by serial passages of H-type BSE in bovinized mice

 

Kentaro Masujin, Naoko Tabeta, Ritsuko Miwa, Kohtaro Miyazawa, Hiroyuki Okada, Shirou Mohri and Takashi Yokoyama National Institute of Animal Health; Tsukuba, Japan

 

H-type bovine spongiform encephalopathy (BSE) is an atypical form of BSE, and has been detected in several European countries, and North America. Transmission studies of H-type BSE led to the emergence of the classical BSE (C-BSE) phenotypes during passages in inbred wild type and bovinized PrP-overexpressing transgenic mice. In this study, we conducted serial passages of Canadian H-type BSE isolate in bovinized PrP-overexpressing transgenic mice (TgBoPrP). H-type BSE isolate was transmitted to TgBoPrP with incubation periods of 320 ± 12.2 d at primary passage. The incubation period of 2nd and 3rd passage were constant (~= 220 d), no clear differences were observed in their biological and biochemical properties. However, at the forth passage, 2 different BSE phenotypes were confirmed; one is shorter survival times (109 ± 4 d) and the other is longer survival times. TgBoPrP mice with longer incubation period showed the H-type phenotype of PrPsc profile and pathology. However, those of shorter incubation period were different phenotypes from previously existed BSE prions (C-BSE, L-type BSE, and H-type BSE).

 

*** This study imply the possibility that the novel BSE prions with high virulence in cattle will be emerged during intraspecies transmission.

 


 

www.landesbioscience.com

 

please see ;

 

Thursday, August 15, 2013

 

The emergence of novel BSE prions by serial passages of H-type BSE in bovinized mice

 


 

Sunday, September 1, 2013

 

*** Evaluation of the Zoonotic Potential of Transmissible Mink Encephalopathy

 

We previously described the biochemical similarities between PrPres derived from L-BSE infected macaque and cortical MM2 sporadic CJD: those observations suggest a link between these two uncommon prion phenotypes in a primate model (it is to note that such a link has not been observed in other models less relevant from the human situation as hamsters or transgenic mice overexpressing ovine PrP [28]). We speculate that a group of related animal prion strains (L-BSE, c-BSE and TME) would have a zoonotic potential and lead to prion diseases in humans with a type 2 PrPres molecular signature (and more specifically type 2B for vCJD)

 

snip...

 

Together with previous experiments performed in ovinized and bovinized transgenic mice and hamsters [8,9] indicating similarities between TME and L-BSE, the data support the hypothesis that L-BSE could be the origin of the TME outbreaks in North America and Europe during the mid-1900s.

 


 

Monday, October 10, 2011

 

EFSA Journal 2011 The European Response to BSE: A Success Story

 

snip...

 

EFSA and the European Centre for Disease Prevention and Control (ECDC) recently delivered a scientific opinion on any possible epidemiological or molecular association between TSEs in animals and humans (EFSA Panel on Biological Hazards (BIOHAZ) and ECDC, 2011). This opinion confirmed Classical BSE prions as the only TSE agents demonstrated to be zoonotic so far ***but the possibility that a small proportion of human cases so far classified as "sporadic" CJD are of zoonotic origin could not be excluded. Moreover, transmission experiments to non-human primates suggest that some TSE agents in addition to Classical BSE prions in cattle (namely L-type Atypical BSE, Classical BSE in sheep, transmissible mink encephalopathy (TME) and chronic wasting disease (CWD) agents) might have zoonotic potential.

 

snip...

 


 


 

see follow-up here about North America BSE Mad Cow TSE prion risk factors, and the ever emerging strains of Transmissible Spongiform Encephalopathy in many species here in the USA, including humans ;

 


 

Thursday, August 12, 2010

 

Seven main threats for the future linked to prions

 

First threat

 

The TSE road map defining the evolution of European policy for protection against prion diseases is based on a certain numbers of hypotheses some of which may turn out to be erroneous. In particular, a form of BSE (called atypical Bovine Spongiform Encephalopathy), recently identified by systematic testing in aged cattle without clinical signs, may be the origin of classical BSE and thus potentially constitute a reservoir, which may be impossible to eradicate if a sporadic origin is confirmed.

 

***Also, a link is suspected between atypical BSE and some apparently sporadic cases of Creutzfeldt-Jakob disease in humans. These atypical BSE cases constitute an unforeseen first threat that could sharply modify the European approach to prion diseases.

 

Second threat

 

snip...

 


 

TSS

 

Saturday, January 18, 2014

GERMANY DETECTS A CASE OF ATYPICAL BSE Jan 17, 2014

 
 

“Mad Cow Disease” Crops Up in German Beef Cattle Jan 17, 2014 | Katharina Schwan | Outbreak News -
 
 
For the first time since 2007, a case of atypical Bovine spongiform Encephalitis (BSE) was identified in a beef cow in the German state of Brandenburg. The Brandenburg Ministry of Health released a report stating that the cow had not shown symptoms of the disease and thus had been slaughtered to prepare the meat for consumption. However, since the animal was more than 10 years old, it underwent an obligatory BSE-test, which came back positive.
 
“This [atypical] form occurs rarely, and differentiates from classical BSE by developing spontaneously and only in older animals,” explains veterinarian Klaus Reimer. HealthMap reported on a similar case in 2012, when a case of atypical BSE was found in a dairy cow in California.
 
The slaughtered animal was discarded according to the proper regulations and the slaughterhouse has been disinfected. Although it is unlikely that BSE can be transmitted through animal-to-animal contact, the herd from which the affected animal came is currently under quarantine and the necessary epidemiological investigations are underway.
 
To reduce the risk of BSE transmission to humans, Germany has strict regulations in place on how to handle slaughtered beef. Animal by-products that are not fit for human consumption, such as the bowel, the skull and the spine, have to be removed and discarded properly. All beef cows eight years and older undergo a BSE “rapid test” that quickly screens cattle for BSE. “Due to these protective measures, no health risk exists for consumers,” said a spokesperson for the German Federal Department of Agriculture.
 
BSE is a progressive, often fatal, neurological disease in cattle that develops due to infection by a prion. Prions are not well understood, yet the CDC explains that the most widely accepted theory is that prions are modified proteins, or prion proteins, that can damage the central nervous system of cattle. Researchers believe the disease may have originated in animals that were fed animal by-products infected with BSE. A similar disease exists in humans known as Creutzfeldt-Jakob Disease (CJD).
 
Since BSE develops over long periods of time, cattle may not show any signs of infection for several years. With time, symptoms may include nervous or aggressive behavior, abnormal posture, lack of coordination, decreased milk production and weight loss. BSE is not contagious and cannot be transmitted between animals, nor can the disease be spread through dairy products.
 
 
 
 
13.01.2014BSE: Erste Kontakttiere ermittelt Potsdam – Im Zusammenhang mit der bei einem Rind im Landkreis Oder-Spree festgestellten atypischen BSE (Bovine Spongiforme Encephalopathie) konnten jetzt erste Kontakttiere ermittelt werden. „Nach ersten Ermittlungen konnten bisher sieben Nachkommen ermittelt werden, von denen sich noch zwei Tiere im Bestand befinden“, so Landestierarzt Dr. Klaus Reimer. Er verweist darauf, dass die Nachforschungen zur sogenannten Geburtskohorte intensiv weitergeführt werden.
 
Bisher haben die epidemiologischen Ermittlungen ergeben, dass das betroffene Tier insgesamt 7 Nachkommen hatte, von denen derzeit noch 2 Tiere leben. Die Ermittlung der Geburtskohorte gestaltet sich schwieriger und dauert derzeit noch an. Dazu müssen die Bestandsbücher des Betriebes und die Datenbank des Herkunftssicherungs- und Informationssystems Tiere (HIT), insbesondere für den zurückliegenden geburtsnahen Zeitraum (1 Jahr vor und 1 Jahr nach der Geburt des betroffenen Tieres), analysiert werden. Auf jeden Fall wird sichergestellt, dass die ermittelten Nachkommen und die Tiere der Geburtskohorte nicht in den Nahrungskreislauf gelangen.
 
Die festgestellte atypische BSE ist im Rahmen der routinemäßigen Schlachtuntersuchung im Schlachthof festgestellt worden und ein Zeichen dafür, dass das System der vorbeugenden und vorsorglichen Kontrolle in Bezug auf BSE funktioniert. Reimer geht davon aus, dass es sich bei der festgestellten Erkrankung um einen Einzelfall handelt. „Wir führen jährlich etwa 8000 bis 10.000 BSE-Schnelltests bei Schlachttieren durch. Von 2007 bis 2013 gab es keinen positiven Befund“, so der Landstierarzt.
 
Bis zum Abschluss der epidemiologischen Ermittlungen bleibt die Herde gesperrt. Der Landkreis hat alle notwendigen Maßnahmen ergriffen und wird durch die Task Force des Landes unterstützt.
 
Weitere Informationen:
 
weitere Informationen Atypische BSE (Fragen und Antworten)
 
 
 
 


SEE OIE REPORT HERE;

Saturday, January 18, 2014

Bovine spongiform encephalopathy ,Germany Information received on 17/01/2014

 

 

Monday, October 10, 2011

 EFSA Journal 2011 The European Response to BSE: A Success Story



***Oral Transmission of L-type Bovine Spongiform Encephalopathy in Primate Model


 

***Infectivity in skeletal muscle of BASE-infected cattle


 

***feedstuffs- It also suggests a similar cause or source for atypical BSE in these countries.

http://www.neuroprion.org/resources/pdf_docs/conferences/prion2009/prion2009_bookofabstracts.pdf

 

***Also, a link is suspected between atypical BSE and some apparently sporadic cases of Creutzfeldt-Jakob disease in humans.


 
full text ;

atypical L-type BASE BSE


 

Tuesday, May 1, 2012

BSE MAD COW LETTERS TO USDA (Tom Vilsack, Secretary of Agriculture) and FDA (Magaret Hamburg, Commissioner of FDA) May 1, 2012


 

Sunday, December 15, 2013

FDA PART 589 -- SUBSTANCES PROHIBITED FROM USE IN ANIMAL FOOD OR FEED VIOLATIONS OFFICIAL ACTION INDICATED OIA UPDATE DECEMBER 2013 UPDATE


 

Friday, January 17, 2014

*** Annual report of the Scientific Network on BSE-TSE EFSA, Question No EFSA-Q-2013-01004, approved on 11 December 2013 TECHNICAL REPORT


 

P04.40 A Case Study of Bovine Spongiform Encephalopathy and Variant Creutzfeldt-Jakob Disease in Germany
 
Lewis, R; Krewski, D; Tyshenko, MG. University of Ottawa, McLaughlin Centre, Canada
 
Despite the emergence of Bovine Spongiform Encephalopathy (BSE) throughout Europe, Germany considered itself an oasis that was free of the disease. However, on November 26, 2000 the first domestic case of BSE appeared in the country and public concerns over food and health safety ensued. Germany traditionally is known for its large agriculture and farming sectors with health and environmentally conscientious citizens. The occurrence of BSE within the country borders had dramatic economic and social effects. The response of Germany’s public and politicians far surpassed that of most other countries affected by the disease. In Germany the reaction to BSE and perception of risk was even more intense than that of the United Kingdom, which to date is still the region that has been most affected by BSE and variant Creutzfeldt-Jakob disease (vCJD). Response to BSE was rapid with new policies and high percentage testing of cattle implemented within months. To date, Germany has not had a single case of vCJD.
 
 
 
MISSING the bigger picture i.e. sporadic CJD and BSE/BASE, both of which have been related to the sporadic CJD as well, BOTH of which increased in numbers, and decreased, at or about the same time period of the increase and decrease of BSE cases (BASE however, seems to be increasing). ...tss
 
Subject: CJD DOUBLES IN GERMANY FROM 1993 TO 2005 Date: May 1, 2007 at 8:47 am PST
 
© The Author (2007). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
 
Creutzfeldt–Jakob disease in Germany: a prospective 12-year surveillance U. Heinemann1, A. Krasnianski1, B. Meissner1, D. Varges1, K. Kallenberg2, W. J. Schulz-Schaeffer3, B. J. Steinhoff4, E. M. Grasbon-Frodl5, H. A. Kretzschmar5 and I. Zerr1 1National TSE Reference Center at Department of Neurology, Georg-August University Göttingen, Germany, 2Department of Neuroradiology, Georg-August University Göttingen, Germany, 3Department of Neuropathology, Georg-August University Göttingen, Germany, 4Epilepsy Center Kork, Diakonie Kork, Germany and 5Department of Neuropathology, Ludwig-Maximilian University Munich, Germany
 
Correspondence to: Inga Zerr, MD, National Reference Center for TSE, Department of Neurology, Georg-August University Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, Germany E-mail: IngaZerr@med.uni-goettingen.de
 
Creutzfeldt–Jakob disease (CJD) is a rare and fatal neurodegenerative disorder with a worldwide incidence of 1–1.5 per million. As in other countries, a CJD surveillance unit with a clinical and neuropathological approach was established in Goettingen (Germany) in 1993. Here we report the epidemiological data from a prospective 12-year surveillance. Since 1993, there has been an increasing incidence of CJD, from 0.7 in 1993 to 1.6 in 2005 with a quite stable level since 1998. During this period, the proportion of patients with MV and VV codon 129 genotype rose, possibly because of better identification of atypical subtypes. Six percent of all patients had a PRNP mutation, mainly D178N-129M (FFI), E200K and V210I. Iatrogenic CJD was a rare phenomenon. No patient infected by cadaveric growth hormone extracts was reported. Furthermore, no variant CJD patient has yet been identified in Germany. Differential diagnoses revealed a variety of neurodegenerative diseases, with Alzheimer's disease in the lead. One-third of the non-CJD patients included in this study suffered from a potentially treatable disorder such as metabolic or inflammatory diseases. The incidence and mortality rates in Germany are similar to those in other European countries. In contrast, however, acquired forms, such as iatrogenic and variant CJD are still rare in Germany or have not yet been identified.
 
Key Words: CJD; dementia; epidemiology; diagnosis; CSF; MRI; codon 129 genotype; genetic CJD; reversible/treatable dementia
 
 
 
Copyright © 2006 Elsevier B.V. All rights reserved.
 
Atypical BSE in Germany—Proof of transmissibility and biochemical characterization
 
A. Buschmanna, A. Gretzschela, A.-G. Biacabeb, K. Schiebelc, C. Coronad, C. Hoffmanna, M. Eidena, T. Baronb, C. Casaloned and Martin H. Groschupa, ,
 
aFriedrich-Loeffler-Institut (FLI), Institute for Novel and Emerging Infectious Diseases, Boddenblick 5a, 17493 Greifswald, Insel Riems, Germany bAFSSA-Lyon, Unite ATNC, Lyon, France cInstitut für Biochemie, Universitity Erlangen-Nürnberg, Germany dCEA, Instituto Zooprofilattico di Turino, Turin, Italy
 
Received 11 January 2006; revised 23 May 2006; accepted 2 June 2006. Available online 17 August 2006.
 
Abstract Intensive active surveillance has uncovered two atypical German BSE cases in older cattle which resemble the two different atypical BSE phenotypes that have recently been described in France (designated H-type) and Italy (designated L-type or BASE). The H-type is characterized by a significantly higher molecular size, but a conventional glycopattern of the proteinase K treated abnormal prion protein (PrPSc), while the L-type PrPSc has only a slightly lower molecular size and a distinctly different glycopattern. In this paper we describe the successful transmission of both German atypical BSE cases to transgenic mice overexpressing bovine PrPC. Upon challenge with the L-type, these mice developed BSE after a substantially shorter incubation period than any classical BSE transmission using these mice to date. In contrast, the incubation period was distinctly prolonged when these mice were challenged with the H-type. PrPSc accumulated in the brains of these mice were of the same atypical BSE type that had been used for the transmission. These atypical cases suggest the possible existence of sporadic BSE cases in bovines. It is thus feasible that the BSE epidemic in the UK could have also been initiated by an intraspecies transmission from a sporadic BSE case.
 
Keywords: BSE; Cattle; PrPSc; Biochemical differentiation
 
 
 
Subject: BSE in Germany - Update Covering 2006 compared to USA Date: February 1, 2007 at 3:09 pm PST
 
Released: Feb 1 2007 Germany | BSE in Germany - Update Covering 2006 GM7004 Highlight: In 2006, 16 cases of BSE were confirmed in Germany, compared to 32 in 2005. This brings the total number of BSE cases to 405, since it was first detected in Germany in November 2000. In June 2006, Germany abolished its stricter BSE testing requirements and replaced it with the standard EU testing regime. Beef consumption is still below the pre-BSE level, primarily because of healthier consumer eating habits rather than fears of BSE.
 
snip...
 
BSE tests
 
In 2006, a total of 1,888,053 animals were tested for BSE in Germany, of which 16 BSE
 
cases were confirmed. Of the total, eight cases were discovered through routine testing at
 
slaughter.
 
 
 
GM6020 06/19/2006 Germany Raises BSE Testing Age to EU Level
 
 
 
GM6004 02/16/2006 Germany plans to adjust BSE testing age to EU level
 
 
 
GM6003 01/27/2006 BSE in Germany - Update Covering 2005
 
 
 
GM3006 02/27/2003 German Cattle Identification and Beef Labeling
 
 
 
GM1033 11/27/2001 One year after the detection of BSE in Germany
 
(Includes a detailed outline of the German risk management
 
system)
 
 
 
 
DID THE U.K. START THE BASE EPIDEMIC AS WELL ???
 
 
STRICTLY CONFIDENTIAL
 
 
 
SEE;
 
 
 
 
BSE FRENCH AND GERMANS
 
 
 
SEE;
 
 
 
 
 
 
 
URL DOES NOT WORK AND NO RECORD I CAN FIND...TSS
 
 
In your letter, you accurately state that I am being pressed to take political decisions in this area. This is due to the fact that, in the opinion of experts, BSE may also pose a risk to humans, although the extent of this risk and the conclusions to be drawn are a matter of contention.
 
Great political pressure has built up here in Germany and I have to take account of it. This pressure comes from the field of scientific debate and the media, but above all from Bundestag and the Bundescrat, which has a strong position in the legislative process in Germany. ...94/06.16/11.1
 
 
 
 
British Beef Exports
 
 
 
 
see;
 
 
 
 
BSE-GERMANY PROPOSAL FOR COSMETICS PRODUCTS
 
 
 
SEE ;
 
 
 
 
EXPORT of bone-in beef from UK, to other member state BSE
 
 
see;
 
 
 
 
e) one way for the industry to take the damages action would be for it to send a consignment of beef to Germany after the regulation came into affect, and to have it turned back at the German border.
 
 
 
 
see ;
 
 
 
 
 
CONFIDENTIAL - POLICY AND COMMERCIAL
 
BSE: LEGAL ACTIONS AGAINST GERMANY
 
 
 
see ;
 
 
 
 
 
it's o.k. to poison 3rd world countries with BSE
 
 
CONFIDENTIAL POLICY
 
 
‘’WE WOULD NOT RECOMMEND AGREEING TO A BAN ON OUR EXPORTS TO THIRD COUNTRIES AND THIS HAS NOT FEATURED IN THE RECENT DISCUSSIONS.’’
 
 
 
 
see ;
 
 
 
 
 
Subject: Re: no further BSE-tests in NRW (Germany) From: "Roland Heynkes @ T-Online" Reply-To: Bovine Spongiform Encephalopathy Date: Tue, 29 Jun 1999 00:20:09 +0200 Content-Type: text/plain
 
Dear Terry,
 
 
> Roland, that's rather scarey..............
 
> But, what I find most interesting, is that a country as small as Germany, can
 
> test 5,029 cattle for B.S.E., in about 4 months. But, it takes the U.S.A. 9
 
> years to test 7,749 cattle for B.S.E. With the cattle population in the U.S.,
 
> compared to that of Germany, it would look as if though, they really were not > looking very hard, for B.S.E. in the United States..............
 
> Germany is not so small and about 140,000 dollars for this 5000 tests are peanuts even for Nordrhein-Westfalen which is only a relatively small part of Germany. This are less than 28 dollar for each animal or a few cent per steak. This is essentially nothing and of course much less than the decrease of the prize for cattle as a consequence of the erosion of trust. I am sure we agree that the costs are not the reason for the test stop in NRW or the refusal to test in other countries. The real reason not to test for BSE is of cause the fear to find something.
 
The 5029 Prionics tests in NRW are not comparable with the 7749 tests in the USA, because the Prionics test is much faster and cheaper.
 
best regards
 
Roland Heynkes
 
Erkwiesenstr. 19 D-52072 Aachen (Germany) Tel.: +49 (0)241/932070 Fax: +49 (0)241/932071 email: roland.heynkes@t-online.de http://home.t-online.de/home/Roland.Heynkes
 
FURTHER DISCUSSION on BSE-L about BSE risk in Germany (these are old discussions). ...TSS
 
 
 
Atypical scrapie cases in Germany and France are identified by discrepant reaction patterns in BSE rapid tests.Buschmann A, Biacabe AG, Ziegler U, Bencsik A, Madec JY, Erhardt G, Lühken G, Baron T, Groschup MH. Federal Research Centre for Virus Diseases of Animals, Institute for Novel and Emerging Infectious Diseases, Boddenblick 5a, 17493 Greifswald-Insel Riems, Germany.
 
The intensified surveillance of scrapie in small ruminants in the European Union (EU) has resulted in a substantial increase of the number of diagnosed cases. Four rapid tests which have passed the EU evaluation for BSE testing of cattle are also recommended currently and used for the testing of small ruminants by the EU authorities. These tests include an indirect ELISA (cELISA), a colorimetric sandwich ELISA (sELISA I), a chemiluminescent sandwich ELISA (sELISA II), and a Western blot (WB). To this point, the majority of samples have been screened by using either sELISA I (predominantly in Germany) or WB (predominantly in France). In this study, it is shown that a number of the German and French scrapie cases show inconsistent results using rapid and confirmatory test methods. Forty-eight German sheep, 209 French sheep and 19 French goat transmissible spongiform encephalopathy (TSE) cases were tested. All cases were recognised by the sELISA I and either one of the confirmatory methods (scrapie-associated fibrils (SAF)-immunoblot or immunohistochemistry). Surprisingly, three rapid tests failed to detect a significant number of scrapie cases (29 in France and 24 in Germany). The possible reasons for these inconsistent reaction patterns of scrapie cases are discussed. Similar discrepancies have not been observed during rapid testing of cattle for BSE, the disease for which all diagnostic methods applied have been evaluated.
 
PMID: 15019257 [PubMed - indexed for MEDLINE]
 
 
 
P03.141 Aspects of the Cerebellar Neuropathology in Nor98
 
Gavier-Widén, D1; Benestad, SL2; Ottander, L1; Westergren, E1 1National Veterinary Insitute, Sweden; 2National Veterinary Institute,
 
Norway Nor98 is a prion disease of old sheep and goats. This atypical form of scrapie was first described in Norway in 1998. Several features of Nor98 were shown to be different from classical scrapie including the distribution of disease associated prion protein (PrPd) accumulation in the brain. The cerebellum is generally the most affected brain area in Nor98. The study here presented aimed at adding information on the neuropathology in the cerebellum of Nor98 naturally affected sheep of various genotypes in Sweden and Norway. A panel of histochemical and immunohistochemical (IHC) stainings such as IHC for PrPd, synaptophysin, glial fibrillary acidic protein, amyloid, and cell markers for phagocytic cells were conducted. The type of histological lesions and tissue reactions were evaluated. The types of PrPd deposition were characterized. The cerebellar cortex was regularly affected, even though there was a variation in the severity of the lesions from case to case. Neuropil vacuolation was more marked in the molecular layer, but affected also the granular cell layer. There was a loss of granule cells. Punctate deposition of PrPd was characteristic. It was morphologically and in distribution identical with that of synaptophysin, suggesting that PrPd accumulates in the synaptic structures. PrPd was also observed in the granule cell layer and in the white matter. The pathology features of Nor98 in the cerebellum of the affected sheep showed similarities with those of sporadic Creutzfeldt-Jakob disease in humans.
 
 
 
----- Original Message -----
From: Terry S. Singeltary Sr.
To: TERRY SINGELTARY
Sent: Tuesday, October 27, 2009 12:36 PM
Subject: CJD GERMANY


CJK in Deutschland


Stand 06.10.2009


Jahr sicher wahrscheinlich möglich GSS FFI genetische


CJD


Iatrogen vCJK Inzidenz


1993 24 8 4 1 0 0 0 - 0,7
1994 45 27 26 0 2 4 1 - 0,9
1995 64 23 15 1 2 2 0 - 1,1
1996 55 34 22 1 5 5 1 - 1,1
1997 73 34 31 1 1 6 1 - 1,3
1998 63 54 11 1 3 7 0 - 1,4
1999 68 35 5 0 1 9 1 - 1,3
2000 53 55 4 2 1 7 1 - 1,3
2001 69 55 11 0 3 8 0 - 1,5
2002 52 46 6 0 2 7 0 - 1,2
2003 52 63 8 1 1 3 3 - 1,4
2004 80 60 5 1 4 4 0 - 1,7
2005 62 82 9 0 5 9 2 - 1,8
2006 61 80 8 0 4 5 1 - 1,7
2007 48 83 14 0 3 1 0 - 1,6
2008 57 78 9 0 3 0 0 - 1,6
2009 16 70 8 1 4 1 0 - 1,4*
 
 

suspected CJD cases ≤50 years
 
Year
suspected cases50
definite & probable cases 50
1993
0
0
1994
20
3
1995
14
3
1996
32
5
1997
13
6
1998
20
7
1999
12
7
2000
9
4
2001
15
5
2002
15
4
2003
19
9
2004
10
4
2005
18
8
2006
26
5
2007
28
7
2008
40
4
2009
27
4
2010
20
7
2011
14
4
2012
8
4
2013
7
3
2014
-
-
Gesamt
367
103
 

 
 
 
 
 
However, a BSE expert said that consumption of infected material is the only known way that cattle get the disease under natural conditons.
 
 
*** “In view of what we know about BSE after almost 20 years experience, contaminated feed has been the source of the epidemic,” said Paul Brown, a scientist retired from the National Institute of Neurological Diseases and Stroke. BSE is not caused by a microbe. It is caused by the misfolding of the so-called “prion protein” that is a normal constituent of brain and other tissues. If a diseased version of the protein enters the brain somehow, it can slowly cause all the normal versions to become misfolded. It is possible the disease could arise spontaneously, though such an event has never been recorded, Brown said.
 
 
 
 
*** What irks many scientists is the USDA’s April 25 statement that the rare disease is “not generally associated with an animal consuming infected feed.” The USDA’s conclusion is a “gross oversimplification,” said Dr. Paul Brown, one of the world’s experts on this type of disease who retired recently from the National Institutes of Health. "(The agency) has no foundation on which to base that statement.”
 
 
 
 
2012 ATYPICAL L-TYPE BSE BASE CALIFORNIA ‘confirmed’ Saturday, August 4, 2012
 
*** Final Feed Investigation Summary - California BSE Case - July 2012
 
 
 
 
Saturday, August 14, 2010
 
BSE Case Associated with Prion Protein Gene Mutation (g-h-BSEalabama) and VPSPr PRIONPATHY
 
(see mad cow feed in COMMERCE IN ALABAMA...TSS)
 
 
 
 
Friday, January 17, 2014
 
*** Annual report of the Scientific Network on BSE-TSE EFSA, Question No EFSA-Q-2013-01004, approved on 11 December 2013
 
 
 
 
Sunday, December 15, 2013
 
*** FDA PART 589 -- SUBSTANCES PROHIBITED FROM USE IN ANIMAL FOOD OR FEED VIOLATIONS OFFICIAL ACTION INDICATED OAI UPDATE DECEMBER 2013 UPDATE
 
 
 
 
Saturday, December 21, 2013
 
**** Complementary studies detecting classical bovine spongiform encephalopathy infectivity in jejunum, ileum and ileocaecal junction in incubating cattle ****
 
 
 
 
Wednesday, December 4, 2013
 
*** Bovine Spongiform Encephalopathy; Importation of Bovines and Bovine Products; Final Rule Federal Register / Vol. 78 , No. 233 / Wednesday, December 4, 2013
 
 
 
 
Saturday, November 2, 2013
 
*** APHIS Finalizes Bovine Import Regulations in Line with International Animal Health Standards while enhancing the spread of BSE TSE prion mad cow type disease around the Globe
 
 
 
 
 
 
Tuesday, October 29, 2013
 
VARIANT CJD PRESENTS DIFFERENTLY IN OLDER PATIENTS
 
 
 
 
Wednesday, October 09, 2013
 
*** WHY THE UKBSEnvCJD ONLY THEORY IS SO POPULAR IN IT'S FALLACY, £41,078,281 in compensation REVISED
 
 
 
 
Thursday, October 10, 2013
 
CJD REPORT 1994 increased risk for consumption of veal and venison and lamb
 
 
 
 
Friday, August 16, 2013
 
*** Creutzfeldt-Jakob disease (CJD) biannual update August 2013 U.K. and Contaminated blood products induce a highly atypical prion disease devoid of PrPres in primates
 
 
 
 
WHAT about the sporadic CJD TSE proteins ?
 
WE now know that some cases of sporadic CJD are linked to atypical BSE and atypical Scrapie, so why are not MORE concerned about the sporadic CJD, and all it’s sub-types $$$
 
Creutzfeldt-Jakob Disease CJD cases rising North America updated report August 2013
 
*** Creutzfeldt-Jakob Disease CJD cases rising North America with Canada seeing an extreme increase of 48% between 2008 and 2010 ***
 
 
 
 
Sunday, October 13, 2013
 
*** CJD TSE Prion Disease Cases in Texas by Year, 2003-2012
 
 
 
 
TSS
 

Sunday, November 17, 2013

L-BSE in Genetically Susceptible and Resistant Sheep: Changes in Prion Strain or Phenotypic Plasticity of the Disease-Associated Prion Protein?

L-BSE in Genetically Susceptible and Resistant Sheep: Changes in Prion Strain or Phenotypic Plasticity of the Disease-Associated Prion Protein?
 
Simon Nicot1, Anna Bencsik1, Sergio Migliore2, Dominique Canal1, Mikael Leboidre1, Umberto Agrimi2, Romolo Nonno2 and Thierry Baron1,* + Author Affiliations
 
1Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (Anses), Unité Maladies Neuro-Dégénératives, Lyon Cedex 07, France
 
2Istituto Superiore di Sanità (ISS). Department of Veterinary Public Health and Food Safety, Rome, Italy ↵*Corresponding author: Thierry Baron, Anses. Laboratoire de Lyon. 31, avenue Tony Garnier, 69364 Lyon cedex 07, France. Phone: (+33) 4 78 72 65 43. Fax: (+33) 4 78 61 91 45. thierry.baron@anses.fr
 
Abstract
 
Background. Sheep with prion protein (PrP) gene polymorphisms QQ171 and RQ171 were shown to be susceptible to the prion causing L-type bovine spongiform encephalopathy (L-BSE), although RQ171 sheep specifically propagated a distinctive prion molecular phenotype in their brains, characterized by a high molecular mass protease-resistant PrP fragment (HMM PrPres), distinct from L-BSE in QQ171 sheep.
 
Methods. The resulting infectious and biological properties of QQ171 and RQ171 ovine L-BSE prions were investigated in transgenic mice expressing either bovine or ovine PrP.
 
Results. In both mouse lines, ovine L-BSE transmitted similarly to cattle-derived L-BSE, with respect to survival periods, histopathology, biochemical features of PrPres in the brain, as well as splenotropism, clearly differing from ovine classical BSE or from scrapie strain CH1641. Nevertheless and unexpectedly, HMM PrPres was found in the spleen of ovine PrP transgenic mice infected with L-BSE from RQ171 sheep at first passage, reminiscent, in lymphoid tissues only, of the distinct PrPres features found in RQ171 sheep brains.
 
Conclusions. The L-BSE agent differs from both ovine C-BSE or CH1641 scrapie maintaining its specific strain properties after passage in sheep, although striking PrPres molecular changes could be found in RQ171 sheep and in the spleen of ovine PrP transgenic mice. Received April 24, 2013. Revision received September 2, 2013. Accepted September 20, 2013. © The Author 2013. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.
 
 
 
 
re-BSE in goats can be mistaken for scrapie
 
 
 
Wednesday, January 18, 2012
 
BSE IN GOATS CAN BE MISTAKEN FOR SCRAPIE
 
February 1, 2012
 
 
 
Wednesday, January 18, 2012
 
Selection of Distinct Strain Phenotypes in Mice Infected by Ovine Natural Scrapie Isolates Similar to CH1641 Experimental Scrapie
 
Journal of Neuropathology & Experimental Neurology:
 
February 2012 - Volume 71 - Issue 2 - p 140–147
 
 
 
Thursday, July 14, 2011
 
Histopathological Studies of "CH1641-Like" Scrapie Sources Versus Classical Scrapie and BSE Transmitted to Ovine Transgenic Mice (TgOvPrP4)
 
 
 
SHEEP AND BSE
 
PERSONAL AND CONFIDENTIAL
 
SHEEP AND BSE
 
A. The experimental transmission of BSE to sheep.
 
Studies have shown that the ''negative'' line NPU flock of Cheviots can be experimentally infected with BSE by intracerebral (ic) or oral challenge (the latter being equivalent to 0.5 gram of a pool of four cow brains from animals confirmed to have BSE).
 
 
 
RB264
 
BSE - TRANSMISSION STUDIES
 
 
 
Wednesday, January 18, 2012
 
Selection of Distinct Strain Phenotypes in Mice Infected by Ovine Natural Scrapie Isolates Similar to CH1641 Experimental Scrapie
 
Journal of Neuropathology & Experimental Neurology:
 
February 2012 - Volume 71 - Issue 2 - p 140–147
 
 
 
Saturday, November 02, 2013
 
OREGON DETECTS SCRAPIE
 
 
 
Tuesday, February 01, 2011

Sparse PrP-Sc accumulation in the placentas of goats with naturally acquired scrapie

Research article
http://scrapie-usa.blogspot.com/2011/02/sparse-prp-sc-accumulation-in-placentas.html
Thursday, June 2, 2011

USDA scrapie report for April 2011 NEW ATYPICAL NOR-98 SCRAPIE CASES Pennsylvania AND California
http://nor-98.blogspot.com/2011/06/usda-scrapie-report-for-april-2011-new.html
UPDATE PLEASE NOTE ;
AS of June 30, 2011,

snip...

INCLUDING 10 POSITIVE GOATS FROM THE SAME HERD (FIGURE 7).

snip...

see updated APHIS scrapie report ;
http://www.aphis.usda.gov/animal_health/animal_diseases/scrapie/downloads/monthly_scrapie_rpt.pps
Tuesday, February 01, 2011

Sparse PrP-Sc accumulation in the placentas of goats with naturally acquired scrapie

Research article

snip...

Date: Tuesday, February 01, 2011 5:03 PM

To: Mr Terry Singeltary

Subject: Your comment on BMC Veterinary Research 2011, 7:7

Dear Mr Singeltary

Thank you for contributing to the discussion of BMC Veterinary Research 2011, 7:7 .

Your comment will be posted within 2 working days, as long as it contributes to the topic under discussion and does not breach patients' confidentiality or libel anyone. You will receive a further notification by email when the posting appears on the site or if it is rejected by the moderator.

Your posting will read:

Mr Terry Singeltary,

retired

Scrapie cases Goats from same herd USA Michigan

Comment: " In spite of the poorly defined effects of PRNP genetics, scrapie strain, dose, route and source of infection, the caprine placenta may represent a source of infection to progeny and herd mates as well as a source of persistent environmental contamination. "

Could this route of infection be the cause of the many cases of Goat scrapie from the same herd in Michigan USA ?

Has this been investigated ?

(Figure 6) including five goat cases in FY 2008 that originated from the same herd in Michigan. This is highly unusual for goats, and I strenuously urge that there should be an independent investigation into finding the common denominator for these 5 goats in the same herd in Michigan with Scrapie. ...

Kind Regards, Terry
Thursday, January 07, 2010

Scrapie and Nor-98 Scrapie November 2009 Monthly Report Fiscal Year 2010 and FISCAL YEAR 2008
http://scrapie-usa.blogspot.com/2010/01/scrapie-and-nor-98-scrapie-november.html
In FY 2010, 72 cases of classical Scrapie and 5 cases of Nor-98 like Scrapie were confirmed...
http://www.aphis.usda.gov/animal_health/animal_diseases/scrapie/downloads/yearly_report.ppsx
Scrapie Nor-98 like case in California FY 2011 AS of December 31, 2010.

Scrapie cases in goats FY 2002 - 2011 AS of December 31, 2010 Total goat cases = 21 Scrapie cases, 0 Nor-98 like Scrapie cases (21 field cases, 0 RSSS cases)

Last herd with infected goats disignated in FY 2008 Michigan 8 cases
http://www.aphis.usda.gov/animal_health/animal_diseases/scrapie/downloads/monthly_scrapie_rpt.pps
Tuesday, February 01, 2011

Sparse PrP-Sc accumulation in the placentas of goats with naturally acquired scrapie

Research article
http://www.biomedcentral.com/1746-6148/7/7/abstract
http://www.biomedcentral.com/content/pdf/1746-6148-7-7.pdf
"In spite of the poorly defined effects of PRNP genetics, scrapie strain, dose, route and source of infection, the caprine placenta may represent a source of infection to progeny and herd mates as well as a source of persistent environmental contamination."

Could this route of infection be the cause of the many cases of Goat scrapie from the same herd in Michigan USA ?

Has this been investigated ?

(Figure 6) including five goat cases in FY 2008 that originated from the same herd in Michigan. This is highly unusual for goats, and I strenuously urge that there should be an independent investigation into finding the common denominator for these 5 goats in the same herd in Michigan with Scrapie. ...

Kind Regards, Terry
SNIP...
Scrapie Nor-98 like case in California FY 2011 AS of December 31, 2010.

Scrapie cases in goats FY 2002 - 2011 AS of December 31, 2010 Total goat cases = 21 Scrapie cases, 0 Nor-98 like Scrapie cases (21 field cases, 0 RSSS cases)

Last herd with infected goats disignated in FY 2008 Michigan 8 cases
http://www.aphis.usda.gov/animal_health/animal_diseases/scrapie/downloads/monthly_scrapie_rpt.pps
UPDATED RESPONSE ON MY CONCERNS OF GOAT SCRAPIE IN MICHIGAN ;

----- Original Message -----

From: "BioMed Central Comments"

To:

Sent: Wednesday, February 16, 2011 4:13 AM

Subject: Your comment on BMC Veterinary Research 2011, 7:7

Your discussion posting "Scrapie cases Goats from same herd USA Michigan" has been rejected by the moderator as not being appropriate for inclusion on the site.

Dear Mr Singeltary,

Thank you for submitting your comment on BMC Veterinary Research article (2011, 7:7). We have read your comment with interest but we feel that only the authors of the article can answer your question about further investigation of the route of infection of the five goats in Michigan. We advise that you contact the authors directly rather than post a comment on the article.

With best wishes,

Maria

Maria Kowalczuk, PhD Deputy Biology Editor BMC-series Journals

BioMed Central 236 Gray's Inn Road London, WC1X 8HB

+44 20 3192 2000 (tel) +44 20 3192 2010 (fax)

W: www.biomedcentral.com E:
Maria.Kowalczuk@biomedcentral.com

Any queries about this decision should be sent to comments@biomedcentral.com

Regards

BMC Veterinary Research

SNIP...PLEASE SEE FULL TEXT ;

Tuesday, February 01, 2011

Sparse PrP-Sc accumulation in the placentas of goats with naturally acquired scrapie

Research article
http://scrapie-usa.blogspot.com/2011/02/sparse-prp-sc-accumulation-in-placentas.html
Thursday, March 29, 2012

atypical Nor-98 Scrapie has spread from coast to coast in the USA 2012

NIAA Annual Conference April 11-14, 2011San Antonio, Texas
http://nor-98.blogspot.com/2012/03/atypical-nor-98-scrapie-has-spread-from.html


***SCRAPIE GOATS CALIFORNIA 13 CASES TO DATE ! ***

***SCRAPIE GOATS MICHIGAN 8 CASES TO DATE ! ***

(an unusually high amount of scrapie documented in goats for a happenstance of bad luck, or spontaneous event, THAT DOES NOT HAPPEN IN OTHER STATES ??? )

Sunday, June 2, 2013

Characterisation of an Unusual TSE in a Goat by Transmission in Knock-in Transgenic Mice
http://transmissiblespongiformencephalopathy.blogspot.com/2013/06/characterisation-of-unusual-tse-in-goat.html

Friday, July 26, 2013

Voluntary Scrapie Program USA UPDATE July 26, 2013 increase in FY 2013 is not statistically meaningful due to the sample size
http://scrapie-usa.blogspot.com/2013/07/voluntary-scrapie-program-usa-update.html

 
SUMMARY REPORT CALIFORNIA atypical L-type BASE BOVINE SPONGIFORM ENCEPHALOPATHY CASE INVESTIGATION JULY 2012
 
Summary Report BSE 2012
 
Executive Summary
 
 
 
Saturday, August 4, 2012
 
Final Feed Investigation Summary - California atypical L-type BASE BSE Case - July 2012
 
 
 
Saturday, August 4, 2012
 
Update from APHIS Regarding Release of the Final Report on the atypical L-type BASE BSE Epidemiological Investigation
 
 
 
Saturday, November 2, 2013
 
APHIS Finalizes Bovine Import Regulations in Line with International Animal Health Standards while enhancing the spread of BSE TSE prion mad cow type disease around the Globe
 
 
 
I AGREE WITH MR. BULLARD, it’s all about trade and money, BSE TSE PRION aka mad cow type disease and sound science there from, was thrown out the window by the USDA et al that fateful day in December 23, 2003, when the USDA lost it’s ‘gold card’ of supposedly being BSE FREE, (that was and still is a sad joke though), that’s when mad cow junk science was adopted by the USDA...
 
see why below...kind regards, terry
 
 
Monday, November 4, 2013
 
*** R-CALF Bullard new BSE rule represents the abrogation of USDA’s responsibility to protect U.S. consumers and the U.S. cattle herd from the introduction of foreign animal disease
 
 
 
Saturday, November 2, 2013
 
Exploring the risks of a putative transmission of BSE to new species
 
 
 
Wednesday, October 30, 2013
 
SPECIFIED RISK MATERIAL (SRM) CONTROL VERIFICATION TASK FSIS NOTICE 70-13 10/30/13
 
 
 
Wednesday, September 25, 2013
 
Inspections, Compliance, Enforcement, and Criminal Investigations BSE TSE PRION 2013
 
 
 
Sunday, September 1, 2013
 
Evaluation of the Zoonotic Potential of Transmissible Mink Encephalopathy
 
We previously described the biochemical similarities between PrPres derived from L-BSE infected macaque and cortical MM2 sporadic CJD: those observations suggest a link between these two uncommon prion phenotypes in a primate model (it is to note that such a link has not been observed in other models less relevant from the human situation as hamsters or transgenic mice overexpressing ovine PrP [28]). We speculate that a group of related animal prion strains (L-BSE, c-BSE and TME) would have a zoonotic potential and lead to prion diseases in humans with a type 2 PrPres molecular signature (and more specifically type 2B for vCJD)
 
snip...
 
Together with previous experiments performed in ovinized and bovinized transgenic mice and hamsters [8,9] indicating similarities between TME and L-BSE, the data support the hypothesis that L-BSE could be the origin of the TME outbreaks in North America and Europe during the mid-1900s.
 
 
 
MAD COW TESTING ONLY CATCHES SOME MAD COWS
 
Saturday, October 19, 2013
 
A comparative study of modified confirmatory techniques and additional immuno-based methods for non-conclusive autolytic Bovine spongiform encephalopathy cases
 
 
 
Wednesday, October 09, 2013
 
WHY THE UKBSEnvCJD ONLY THEORY IS SO POPULAR IN IT'S FALLACY, £41,078,281 in compensation REVISED
 
 
 
Thursday, October 10, 2013
 
CJD REPORT 1994 increased risk for consumption of veal and venison and lamb
 
 
 
Monday, October 14, 2013
 
Researchers estimate one in 2,000 people in the UK carry variant CJD proteins
 
 
 
WHAT about the sporadic CJD TSE proteins ?
 
WE now know that some cases of sporadic CJD are linked to atypical BSE and atypical Scrapie, so why are not MORE concerned about the sporadic CJD, and all it’s sub-types $$$
 
 
Sunday, August 11, 2013
 
Creutzfeldt-Jakob Disease CJD cases rising North America updated report August 2013
 
Creutzfeldt-Jakob Disease CJD cases rising North America with Canada seeing an extreme increase of 48% between 2008 and 2010
 
 
 
Sunday, October 13, 2013
 
CJD TSE Prion Disease Cases in Texas by Year, 2003-2012
 
 
 
Tuesday, September 24, 2013
 
NORDION (US), INC., AND BIOAXONE BIOSCIENCES, INC., Settles $90M Mad Cow TSE prion Contamination Suit Cethrin(R)
 
Case 0:12-cv-60739-RNS Document 1 Entered on FLSD Docket 04/26/2012 Page 1 of 15
 
 

Saturday, November 16, 2013

Management of neurosurgical instruments and patients exposed to creutzfeldt-jakob disease 2013 December

Infect Control Hosp Epidemiol.
http://creutzfeldt-jakob-disease.blogspot.com/2013/11/management-of-neurosurgical-instruments.html
 
 
TSS