Brazil evaluate the implementation of health rules on animal by-products and derived products SRM BSE TSE PRION aka MAD COW DISEASE
| Country | Brazil |
| Audit number | 2013-6742 |
| Title | evaluate the implementation of health rules on animal by-products and derived products |
| Audit period | Apr 2013 |
| Published | 25/09/2013 |
| Report |  (243 Kb)  |
| - Competent Authority respone to report
recommendations (65Kb)
|
SEE BSE SRMS. ...TSS
EU legislation allows the use of processed animal protein for the
production of pet food. However, for ease of reference and in order to retain
the terminology used in Brazil, the terms “animal meal” (or “poultry meal”,
etc.) are used throughout the report.
2 The central competent authority declared that fallen bovine and pigs
(either dead at farm or during transport) are not used for production of meat
and bone meal. These animals are either buried or burned at farms or, if death
occurs during transport, they are incinerated at slaughterhouse premises
following a pathological examination.
The following table presents the figures provided by the competent
authority concerning the production of ABP and the volume of animal meal
obtained per species in 2011 and 2012. species
2011 (in tonnes) 2012 (in tonnes)
ABP meals ABP meals
poultry 2,965,055 807,311 2,872,896 782,803
bovine 836,129 240,392 978,113 291,767
pigs 6,145 1,629 18,238 4,993
bovine / pigs (mixed) 3,239,819 895,147 3,528,385 976,592
other 2,289 557 696 171
* the data does not reflect the quantities of blood and feather meal
According to the data presented by the competent authority, in 2011 and in 2012,
the export to the EU, respectively amounted to:
• 2,260 and 2,590 tonnes of processed pet food, dispatched in packagings
intended for the final customer, and
• 19,640 and 34,342 tonnes of ABP destined for production of pet food,
mainly in blocks of deep-frozen material of poultry origin.
5 FINDINGS AND CONCLUSIONS
SNIP...
Findings
5.2.2.1 ABP used for production
Brazil is recognised, since 2012, as a country of negligible BSE risk (see
section 4.2). The competent authority declared that a policy concerning SRM in
in place and all slaughterhouses for ruminants must remove and dispose of SRM.
Only ileum is considered as SRM from the entire intestinal tract, therefore all
other parts of bovine intestines are considered fit for human consumption. These
are harvested and placed on the local market or exported to other third
countries.
• In the bovine slaughterhouse visited SRM was removed and placed,
unmarked, in special containers for further disposal. Bovine animals that died
during transport were examined and subsequently incinerated in the
slaughterhouse's incineration facility. The SFA inspector responsible for
official controls in this slaughterhouse stated that in 2012 there were 11 such
animals. He also stated that bovine foetuses are regularly found during
post-mortem examination of cows and, in such situations, they are collected
together with other ABP and dispatched for processing in an attached processing
plant. The audit team noted that the obtained animal meals were dispatched to
pet food plants exporting processed pet food to the EU.
• In both poultry slaughterhouses visited, birds which died during
transport to the slaughterhouses were mixed together with other ABP originating
from the slaughtering process and were sent for processing. In one of the
slaughterhouses, records showed that in
Friday, December 07, 2012
ATYPICAL BSE BRAZIL 2010 FINALLY CONFIRMED OIE 2012
Wednesday, December 19, 2012
Scientific Report of the European Food Safety Authority on the Assessment
of the Geographical BSE Risk (GBR) of Brazil
Monday, August 26, 2013
***The Presence of Disease-Associated Prion Protein in Skeletal Muscle of
Cattle Infected with Classical Bovine Spongiform Encephalopathy
Monday, September 02, 2013
Atypical BSE: role of the E211K prion polymorphism
Research Project: TRANSMISSION, DIFFERENTIATION, AND PATHOBIOLOGY OF
TRANSMISSIBLE SPONGIFORM ENCEPHALOPATHIES
Location: Virus and Prion Research Unit
Sunday, September 1, 2013
Evaluation of the Zoonotic Potential of Transmissible Mink Encephalopathy
We previously described the biochemical similarities between PrPres derived
from L-BSE infected macaque and cortical MM2 sporadic CJD: those observations
suggest a link between these two uncommon prion phenotypes in a primate model
(it is to note that such a link has not been observed in other models less
relevant from the human situation as hamsters or transgenic mice overexpressing
ovine PrP [28]). We speculate that a group of related animal prion strains
(L-BSE, c-BSE and TME) would have a zoonotic potential and lead to prion
diseases in humans with a type 2 PrPres molecular signature (and more
specifically type 2B for vCJD)
snip...
Together with previous experiments performed in ovinized and bovinized
transgenic mice and hamsters [8,9] indicating similarities between TME and
L-BSE, the data support the hypothesis that L-BSE could be the origin of the TME
outbreaks in North America and Europe during the mid-1900s.
Monday, March 25, 2013
Minnesota Firm Recalls Bone-In Ribeye That May Contain Specified Risk Materials Recall Release CLASS II RECALL FSIS-RC-024-2013 http://madcowusda.blogspot.com/2013/03/minnesota-firm-recalls-bone-in-ribeye.html
Minnesota Firm Recalls Bone-In Ribeye That May Contain Specified Risk Materials Recall Release CLASS II RECALL FSIS-RC-024-2013 http://madcowusda.blogspot.com/2013/03/minnesota-firm-recalls-bone-in-ribeye.html
Síndrome de Alpers uma variante da Doença de Creutzfeldt-Jakob?
Alpers’ disease a variant of Creutzfeldt-Jakob Disease?
Henrique Pott Jr.1, Maria Cristina Furian Ferreira2, Amilcar Castro
de
Mattos3
ABSTRACT
The dementia, is usually associated with other neurological abnormalities,
and a definitive diagnosis of most syndromes depends on neuropathological
examination. Creutzfeldt-Jakob disease in children presents neuropathological
examination similar to Alpers’ disease, which have given attention to the
differential diagnosis between these syndromes. The aim of this study was to
report a case of progressive degenerative spongiform encephalopathy in infancy
with study of autopsy. Keywords. Dementia, Differential Diagnosis,
Creutzfeldt-Jakob Syndrome, Alpers Syndrome. Citation. Pott Jr. H, Ferreira MCF,
Mattos AC. Alpers’ disease a variant of Creutzfeldt-Jakob Disease?
snip...
Case Description
Female patient, 5 years, with frame clinical and progressive
encephalopathy in our hospital since 6 months of age. As showed inrespiratory
sufficiency, was kept breathing assist from since that date. Clinical data of
early admission exclude the possibility of secondary ischemic to trauma during
dleivery. The worsening progressive neurological reflexes, including deep, led
to succesive clinical and laboratory investigations pouco enlightening.
snip, see full text ;
Creutzfeldt Jakob disease
The agenda than revenge
By Nathália Kneipp Sena on 14/08/2012 in issue 707
Every time the national press exposes the possible existence of the disease
in Brazil popularly known as "mad cow disease", the news dies on the beach. This
happens because there is insufficient evidence to sensationalism desired (and
lasting) or potential for a diplomatic crisis - ruin the fortunes of kings
livestock and widespread burning of politicians and bureaucrats - or for the
sacrifice of entire herds, as happened across the Sea, UK.
The ordeal of the victims and those affected by prion disease and their
families, which already occurs in the country for decades, and is considered
minor misfortune taboo subject, plot that disenchanted opposite its theoretical
complexity and escalating scientific terms that surround the "discovery" and the
manifestations of the "prion" - pathogenic protein acquired by inheritance or
contagion - a silent serial killer who for centuries decimated several species
of animals worldwide, including humans.
The supposed rarity of Creutzfeldt-Jakob disease (CJD) in humans
manifestation of a pathogenic protein, which is also identified in bovine
spongiform encephalopathy, or BSE (bovine acronym of the English expression
spongiform encephalopathy), or "mad cow disease , "comes to be stated on the
website of the Ministry of Health as nonexistent (no record) in Brazil since
1994.
Victims of CJD in Brazil
Read more at: https://bitly.com/SWfcKb
***
[Nathália Kneipp Sena is a journalist, Brasília, DF]
Thursday, February 14, 2013
The Many Faces of Mad Cow Disease Bovine Spongiform Encephalopathy BSE and
TSE prion disease
Tuesday, March 05, 2013
A closer look at prion strains Characterization and important implications
Prion
7:2, 99–108; March/April 2013; © 2013 Landes Bioscience
Sunday, March 31, 2013
Creutzfeldt Jakob Disease CJD worlds youngest documented victim, 11 years
old, shall we pray
Thursday, September 26, 2013
Minimise transmission risk of CJD and vCJD in healthcare settings Guidance
Sunday, July 21, 2013
Welsh Government and Food Standards Agency Wales Joint Public Consultation
on the Proposed Transmissible Spongiform Encephalopathies (Wales) Regulations
2013 Singeltary Submission WG18417
Friday, August 16, 2013
*** Creutzfeldt-Jakob disease (CJD) biannual update August 2013 U.K. and
Contaminated blood products induce a highly atypical prion disease devoid of
PrPres in primates
Sunday, August 11, 2013
Creutzfeldt-Jakob Disease CJD cases rising North America updated report
August 2013
*** Creutzfeldt-Jakob Disease CJD cases rising North America with Canada
seeing an extreme increase of 48% between 2008 and 2010
Sunday, September 08, 2013
Iatrogenic Creutzfeldt-Jakob disease via surgical instruments and
decontamination possibilities for the TSE prion
Wednesday, September 25, 2013
Cleaning, disinfection and sterilization of surface prion contamination
Tuesday, September 24, 2013
NORDION (US), INC., AND BIOAXONE BIOSCIENCES, INC., Settles $90M Mad Cow
TSE prion Contamination Suit Cethrin(R)
Case 0:12-cv-60739-RNS Document 1 Entered on FLSD Docket 04/26/2012 Page 1
of 15
Prion2013
Oral.05: Contaminated blood products induce a highly atypical prion disease
devoid of PrPres in primates
Emmanuel Corney,1 Nina Jaffre,1 Jacqueline Mikol,1 Valerie Durand,1
Christelle Jas-Duval,1,2 Sophie Luccantoni-Freire,1 Evelyne Correia,1 Nathalie
Lescoutra-Etcheqaray,3 Nathalie Streichenberqer,4 Stephane Haik,5 Chryslain
Sumian,3 Paul Brown1 and Jean-Philippe Deslys1
1Commissariat a l'Energie Atomique; Institute of Emerging Diseases and
Innovative Therapies (iMETI); Division of Prions and Related Diseases (SEPIA);
Fontenay-aux- Roses, France; 2EFS·Nord de France; Lille, France; 3MacoPharm;
Tourcoing, France; 4Hospices Civils de Lyon; Prion Unit; Neurobiology
Department; Bron, France; 5Inserm; U 975·CNRS; UMR 7225 - Universite Pierre et
Marie Curie; Paris, France
Background, Concerns about the blood-borne risk of prion infection have
been confirmed by the occurrence in the UK of four transfusion-related
infections of vCJD and an apparently silent infection in an hemophiliac patient.
Asymptomatic incubation periods in prion diseases can extend over decades in
humans. We present here unexpected results of experiments evaluating blood
transmission risk in a non-human primate model.
Material and Methods, Cynomolgus macaques were inoculated with brain or
blood specimens from vCJD infected humans or monkeys. Neuropathological and
biochemical findings were obtained using current methods used for human
patients.
Results, Thirteen out of 23 primates exposed to various human or macaque
blood products exhibited a previously undescribed myelopathic syndrome, devoid
of the classical features of prion disease, notably abnormal prion protein
(PrPres) deposition, whereas the 14 corresponding brain-inoculated donor animals
and 1 transfused animal exhibited the classical vCJD pattern. In passage
experiments, plasma transfusion induced the same atypical phenotype after two
years (again, with no detectable PrPres), whereas the intracerebral inoculation
of spinal cord led to a typical prion disease with cerebral spongiosis and
PrPres accumulation in the brain of the primate recipient. Interestingly,
passage experiments in transgenic mice were largely unsuccessful.
In another experiment designed to test the efficacy of antiprion filters,
three recipients of filtered red blood cells suspended in plasma are still
healthy 4.5 y after transfusion whereas the recipients of unfiltered inocula
died after 2.5 y with the atypical neurological profile.
Conclusion. We describe a new fatal neurological myelopathic syndrome in
monkeys exposed to various vCJD/BSE-infected blood components.
Secondary transmission in primates confirms
(I) the transmissibility of this myelopathy, and
(2) its prion origin which could not be diagnosed as such in the first
recipients.
This myelopathy might be compared in some respects to certain forms of
human lower motor neuron disease, including neuromyelitis optica, the flail arm
syndrome of amyotrophic lateral sclerosis (ALS), and the recently described
FOSMN (facial onset sensory and motor neuronopathy) syndrome.
AD.56: The emergence of novel BSE prions by serial passages of H-type BSE
in bovinized mice
Kentaro Masujin, Naoko Tabeta, Ritsuko Miwa, Kohtaro Miyazawa, Hiroyuki
Okada, Shirou Mohri and Takashi Yokoyama
National Institute of Animal Health; Tsukuba, Japan
H-type bovine spongiform encephalopathy (BSE) is an atypical form of BSE,
and has been detected in several European countries, and North America.
Transmission studies of H-type BSE led to the emergence of the classical BSE
(C-BSE) phenotypes during passages in inbred wild type and bovinized
PrP-overexpressing transgenic mice. In this study, we conducted serial passages
of Canadian H-type BSE isolate in bovinized PrP-overexpressing transgenic mice
(TgBoPrP). H-type BSE isolate was transmitted to TgBoPrP with incubation periods
of 320 ± 12.2 d at primary passage. The incubation period of 2nd and 3rd passage
were constant (~= 220 d), no clear differences were observed in their biological
and biochemical properties. However, at the forth passage, 2 different BSE
phenotypes were confirmed; one is shorter survival times (109 ± 4 d) and the
other is longer survival times. TgBoPrP mice with longer incubation period
showed the H-type phenotype of PrPsc profile and pathology. However, those of
shorter incubation period were different phenotypes from previously existed BSE
prions (C-BSE, L-type BSE, and H-type BSE).
*** This study imply the possibility that the novel BSE prions with high
virulence in cattle will be emerged during intraspecies transmission.
see also ;
Thursday, August 15, 2013
The emergence of novel BSE prions by serial passages of H-type BSE in
bovinized mice
Wednesday, September 25, 2013
Inspections, Compliance, Enforcement, and Criminal Investigations BSE TSE
PRION 2013
Saturday, September 21, 2013
Westland/Hallmark: 2008 Beef Recall A Case Study by The Food Industry
Center January 2010 THE FLIM-FLAM REPORT
•SPECIFIED RISK MATERIALS SRMs are high-risk tissues that could carry the
material associated with bovine spongiform encephalopathy (also known as BSE or
“mad cow disease”).
Tuesday, March 5, 2013
Use of Materials Derived From Cattle in Human Food
and Cosmetics; Reopening of the Comment Period FDA-2004-N-0188-0051 (TSS
SUBMISSION)
FDA believes current regulation protects the public
from BSE but reopens comment period due to new studies
Tuesday, September 17, 2013
USAHA 116TH ANNUAL MEETING October 18 – 24, 2012 CWD, Scrapie, BSE, TSE
prion (September 17, 2013)
Monday, August 27, 2012
Central Valley Meat Company: USDA Did its Job, OK?
Opinion & Contributed Articles
by Dr. Richard Raymond | Aug 27, 2012 Opinion
Dr. Richard Raymond former Undersecretary for Food Safety, U.S. Department
of Agriculture (2005-2008)
TSS
posted by Terry S. Singeltary Sr. at
10:44 AM
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