Thursday, September 26, 2013

Brazil evaluate the implementation of health rules on animal by-products and derived products SRM BSE TSE PRION aka MAD COW DISEASE

Country Brazil
Audit number 2013-6742
Title evaluate the implementation of health rules on animal by-products and derived products
Audit period Apr 2013
Published 25/09/2013
Report open the inspection report (243 Kb)
- Competent Authority respone to report recommendations (65Kb)


EU legislation allows the use of processed animal protein for the production of pet food. However, for ease of reference and in order to retain the terminology used in Brazil, the terms “animal meal” (or “poultry meal”, etc.) are used throughout the report.

2 The central competent authority declared that fallen bovine and pigs (either dead at farm or during transport) are not used for production of meat and bone meal. These animals are either buried or burned at farms or, if death occurs during transport, they are incinerated at slaughterhouse premises following a pathological examination.

The following table presents the figures provided by the competent authority concerning the production of ABP and the volume of animal meal obtained per species in 2011 and 2012. species

2011 (in tonnes) 2012 (in tonnes)

ABP meals ABP meals

poultry 2,965,055 807,311 2,872,896 782,803

bovine 836,129 240,392 978,113 291,767

pigs 6,145 1,629 18,238 4,993

bovine / pigs (mixed) 3,239,819 895,147 3,528,385 976,592

other 2,289 557 696 171

* the data does not reflect the quantities of blood and feather meal According to the data presented by the competent authority, in 2011 and in 2012, the export to the EU, respectively amounted to:

• 2,260 and 2,590 tonnes of processed pet food, dispatched in packagings intended for the final customer, and

• 19,640 and 34,342 tonnes of ABP destined for production of pet food, mainly in blocks of deep-frozen material of poultry origin.



Findings ABP used for production

Brazil is recognised, since 2012, as a country of negligible BSE risk (see section 4.2). The competent authority declared that a policy concerning SRM in in place and all slaughterhouses for ruminants must remove and dispose of SRM. Only ileum is considered as SRM from the entire intestinal tract, therefore all other parts of bovine intestines are considered fit for human consumption. These are harvested and placed on the local market or exported to other third countries.

• In the bovine slaughterhouse visited SRM was removed and placed, unmarked, in special containers for further disposal. Bovine animals that died during transport were examined and subsequently incinerated in the slaughterhouse's incineration facility. The SFA inspector responsible for official controls in this slaughterhouse stated that in 2012 there were 11 such animals. He also stated that bovine foetuses are regularly found during post-mortem examination of cows and, in such situations, they are collected together with other ABP and dispatched for processing in an attached processing plant. The audit team noted that the obtained animal meals were dispatched to pet food plants exporting processed pet food to the EU.

• In both poultry slaughterhouses visited, birds which died during transport to the slaughterhouses were mixed together with other ABP originating from the slaughtering process and were sent for processing. In one of the slaughterhouses, records showed that in

Friday, December 07, 2012


Wednesday, December 19, 2012

Scientific Report of the European Food Safety Authority on the Assessment of the Geographical BSE Risk (GBR) of Brazil

Monday, August 26, 2013

***The Presence of Disease-Associated Prion Protein in Skeletal Muscle of Cattle Infected with Classical Bovine Spongiform Encephalopathy

Monday, September 02, 2013

Atypical BSE: role of the E211K prion polymorphism


Location: Virus and Prion Research Unit

Sunday, September 1, 2013

Evaluation of the Zoonotic Potential of Transmissible Mink Encephalopathy

We previously described the biochemical similarities between PrPres derived from L-BSE infected macaque and cortical MM2 sporadic CJD: those observations suggest a link between these two uncommon prion phenotypes in a primate model (it is to note that such a link has not been observed in other models less relevant from the human situation as hamsters or transgenic mice overexpressing ovine PrP [28]). We speculate that a group of related animal prion strains (L-BSE, c-BSE and TME) would have a zoonotic potential and lead to prion diseases in humans with a type 2 PrPres molecular signature (and more specifically type 2B for vCJD)


Together with previous experiments performed in ovinized and bovinized transgenic mice and hamsters [8,9] indicating similarities between TME and L-BSE, the data support the hypothesis that L-BSE could be the origin of the TME outbreaks in North America and Europe during the mid-1900s.

Monday, March 25, 2013

Minnesota Firm Recalls Bone-In Ribeye That May Contain Specified Risk Materials Recall Release CLASS II RECALL FSIS-RC-024-2013

Síndrome de Alpers uma variante da Doença de Creutzfeldt-Jakob?

Alpers’ disease a variant of Creutzfeldt-Jakob Disease?

Henrique Pott Jr.1, Maria Cristina Furian Ferreira2, Amilcar Castro de



The dementia, is usually associated with other neurological abnormalities, and a definitive diagnosis of most syndromes depends on neuropathological examination. Creutzfeldt-Jakob disease in children presents neuropathological examination similar to Alpers’ disease, which have given attention to the differential diagnosis between these syndromes. The aim of this study was to report a case of progressive degenerative spongiform encephalopathy in infancy with study of autopsy. Keywords. Dementia, Differential Diagnosis, Creutzfeldt-Jakob Syndrome, Alpers Syndrome. Citation. Pott Jr. H, Ferreira MCF, Mattos AC. Alpers’ disease a variant of Creutzfeldt-Jakob Disease?


Case Description

 Female patient, 5 years, with frame clinical and progressive encephalopathy in our hospital since 6 months of age. As showed inrespiratory sufficiency, was kept breathing assist from since that date. Clinical data of early admission exclude the possibility of secondary ischemic to trauma during dleivery. The worsening progressive neurological reflexes, including deep, led to succesive clinical and laboratory investigations pouco enlightening.

snip, see full text ;

Creutzfeldt Jakob disease

The agenda than revenge

By Nathália Kneipp Sena on 14/08/2012 in issue 707

Every time the national press exposes the possible existence of the disease in Brazil popularly known as "mad cow disease", the news dies on the beach. This happens because there is insufficient evidence to sensationalism desired (and lasting) or potential for a diplomatic crisis - ruin the fortunes of kings livestock and widespread burning of politicians and bureaucrats - or for the sacrifice of entire herds, as happened across the Sea, UK.

The ordeal of the victims and those affected by prion disease and their families, which already occurs in the country for decades, and is considered minor misfortune taboo subject, plot that disenchanted opposite its theoretical complexity and escalating scientific terms that surround the "discovery" and the manifestations of the "prion" - pathogenic protein acquired by inheritance or contagion - a silent serial killer who for centuries decimated several species of animals worldwide, including humans.

The supposed rarity of Creutzfeldt-Jakob disease (CJD) in humans manifestation of a pathogenic protein, which is also identified in bovine spongiform encephalopathy, or BSE (bovine acronym of the English expression spongiform encephalopathy), or "mad cow disease , "comes to be stated on the website of the Ministry of Health as nonexistent (no record) in Brazil since 1994.

Victims of CJD in Brazil

Read more at:


[Nathália Kneipp Sena is a journalist, Brasília, DF]

Thursday, February 14, 2013

The Many Faces of Mad Cow Disease Bovine Spongiform Encephalopathy BSE and TSE prion disease

Tuesday, March 05, 2013

A closer look at prion strains Characterization and important implications Prion

7:2, 99–108; March/April 2013; © 2013 Landes Bioscience

Sunday, March 31, 2013

Creutzfeldt Jakob Disease CJD worlds youngest documented victim, 11 years old, shall we pray

Thursday, September 26, 2013

Minimise transmission risk of CJD and vCJD in healthcare settings Guidance

Sunday, July 21, 2013

Welsh Government and Food Standards Agency Wales Joint Public Consultation on the Proposed Transmissible Spongiform Encephalopathies (Wales) Regulations 2013 Singeltary Submission WG18417

Friday, August 16, 2013

*** Creutzfeldt-Jakob disease (CJD) biannual update August 2013 U.K. and Contaminated blood products induce a highly atypical prion disease devoid of PrPres in primates

Sunday, August 11, 2013

Creutzfeldt-Jakob Disease CJD cases rising North America updated report August 2013

*** Creutzfeldt-Jakob Disease CJD cases rising North America with Canada seeing an extreme increase of 48% between 2008 and 2010

Sunday, September 08, 2013

Iatrogenic Creutzfeldt-Jakob disease via surgical instruments and decontamination possibilities for the TSE prion

Wednesday, September 25, 2013

Cleaning, disinfection and sterilization of surface prion contamination

Tuesday, September 24, 2013

NORDION (US), INC., AND BIOAXONE BIOSCIENCES, INC., Settles $90M Mad Cow TSE prion Contamination Suit Cethrin(R)

Case 0:12-cv-60739-RNS Document 1 Entered on FLSD Docket 04/26/2012 Page 1 of 15


Oral.05: Contaminated blood products induce a highly atypical prion disease devoid of PrPres in primates

Emmanuel Corney,1 Nina Jaffre,1 Jacqueline Mikol,1 Valerie Durand,1 Christelle Jas-Duval,1,2 Sophie Luccantoni-Freire,1 Evelyne Correia,1 Nathalie Lescoutra-Etcheqaray,3 Nathalie Streichenberqer,4 Stephane Haik,5 Chryslain Sumian,3 Paul Brown1 and Jean-Philippe Deslys1

1Commissariat a l'Energie Atomique; Institute of Emerging Diseases and Innovative Therapies (iMETI); Division of Prions and Related Diseases (SEPIA); Fontenay-aux- Roses, France; 2EFS·Nord de France; Lille, France; 3MacoPharm; Tourcoing, France; 4Hospices Civils de Lyon; Prion Unit; Neurobiology Department; Bron, France; 5Inserm; U 975·CNRS; UMR 7225 - Universite Pierre et Marie Curie; Paris, France

Background, Concerns about the blood-borne risk of prion infection have been confirmed by the occurrence in the UK of four transfusion-related infections of vCJD and an apparently silent infection in an hemophiliac patient. Asymptomatic incubation periods in prion diseases can extend over decades in humans. We present here unexpected results of experiments evaluating blood transmission risk in a non-human primate model.

Material and Methods, Cynomolgus macaques were inoculated with brain or blood specimens from vCJD infected humans or monkeys. Neuropathological and biochemical findings were obtained using current methods used for human patients.

Results, Thirteen out of 23 primates exposed to various human or macaque blood products exhibited a previously undescribed myelopathic syndrome, devoid of the classical features of prion disease, notably abnormal prion protein (PrPres) deposition, whereas the 14 corresponding brain-inoculated donor animals and 1 transfused animal exhibited the classical vCJD pattern. In passage experiments, plasma transfusion induced the same atypical phenotype after two years (again, with no detectable PrPres), whereas the intracerebral inoculation of spinal cord led to a typical prion disease with cerebral spongiosis and PrPres accumulation in the brain of the primate recipient. Interestingly, passage experiments in transgenic mice were largely unsuccessful.

In another experiment designed to test the efficacy of antiprion filters, three recipients of filtered red blood cells suspended in plasma are still healthy 4.5 y after transfusion whereas the recipients of unfiltered inocula died after 2.5 y with the atypical neurological profile.

Conclusion. We describe a new fatal neurological myelopathic syndrome in monkeys exposed to various vCJD/BSE-infected blood components.

Secondary transmission in primates confirms

(I) the transmissibility of this myelopathy, and

(2) its prion origin which could not be diagnosed as such in the first recipients.

This myelopathy might be compared in some respects to certain forms of human lower motor neuron disease, including neuromyelitis optica, the flail arm syndrome of amyotrophic lateral sclerosis (ALS), and the recently described FOSMN (facial onset sensory and motor neuronopathy) syndrome.

AD.56: The emergence of novel BSE prions by serial passages of H-type BSE in bovinized mice

Kentaro Masujin, Naoko Tabeta, Ritsuko Miwa, Kohtaro Miyazawa, Hiroyuki Okada, Shirou Mohri and Takashi Yokoyama

National Institute of Animal Health; Tsukuba, Japan

H-type bovine spongiform encephalopathy (BSE) is an atypical form of BSE, and has been detected in several European countries, and North America. Transmission studies of H-type BSE led to the emergence of the classical BSE (C-BSE) phenotypes during passages in inbred wild type and bovinized PrP-overexpressing transgenic mice. In this study, we conducted serial passages of Canadian H-type BSE isolate in bovinized PrP-overexpressing transgenic mice (TgBoPrP). H-type BSE isolate was transmitted to TgBoPrP with incubation periods of 320 ± 12.2 d at primary passage. The incubation period of 2nd and 3rd passage were constant (~= 220 d), no clear differences were observed in their biological and biochemical properties. However, at the forth passage, 2 different BSE phenotypes were confirmed; one is shorter survival times (109 ± 4 d) and the other is longer survival times. TgBoPrP mice with longer incubation period showed the H-type phenotype of PrPsc profile and pathology. However, those of shorter incubation period were different phenotypes from previously existed BSE prions (C-BSE, L-type BSE, and H-type BSE).

*** This study imply the possibility that the novel BSE prions with high virulence in cattle will be emerged during intraspecies transmission.

see also ;

Thursday, August 15, 2013

The emergence of novel BSE prions by serial passages of H-type BSE in bovinized mice

Wednesday, September 25, 2013

Inspections, Compliance, Enforcement, and Criminal Investigations BSE TSE PRION 2013

Saturday, September 21, 2013

Westland/Hallmark: 2008 Beef Recall A Case Study by The Food Industry Center January 2010 THE FLIM-FLAM REPORT

•SPECIFIED RISK MATERIALS SRMs are high-risk tissues that could carry the material associated with bovine spongiform encephalopathy (also known as BSE or “mad cow disease”).

Tuesday, March 5, 2013

Use of Materials Derived From Cattle in Human Food and Cosmetics; Reopening of the Comment Period FDA-2004-N-0188-0051 (TSS SUBMISSION)

FDA believes current regulation protects the public from BSE but reopens comment period due to new studies

Tuesday, September 17, 2013

USAHA 116TH ANNUAL MEETING October 18 – 24, 2012 CWD, Scrapie, BSE, TSE prion (September 17, 2013)

Monday, August 27, 2012

Central Valley Meat Company: USDA Did its Job, OK?

Opinion & Contributed Articles

by Dr. Richard Raymond | Aug 27, 2012 Opinion

Dr. Richard Raymond former Undersecretary for Food Safety, U.S. Department of Agriculture (2005-2008)



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