Four BSE cases with an L-BSE molecular profile in cattle from Great Britain
Veterinary Record doi:10.1136/vr.101158 Paper
Four BSE cases with an L-BSE molecular profile in cattle from Great Britain
M. J. Stack, HNC1, M. J. Chaplin, HNC1, L. A. Davis, BSc1, S. Everitt1, M.
M. Simmons, Dr MRCVS1, O. Windl, Dr1, J. Hope, Dr1 and P. Burke, MRCVS2 + Author
Affiliations
1Animal Health and Veterinary Laboratories Agency (AHVLA), TSE Department,
Woodham Lane, Addlestone, Weybridge, Surrey KT15 3NB, UK 2Animal Health and
Welfare Board for England Secretariat, Department for Environment Food and Rural
Affairs, Nobel House, 17 Smith Square, London SW1P 3JR, UK; E-mail for
correspondence: mick.stack@ahvla.gsi.gov.uk Abstract Bovine spongiform
encephalopathy (BSE) is a prion disease of cattle which was first observed in
Great Britain (GB) in 1986. Throughout the subsequent BSE epidemic, cases
identified by passive surveillance have shown consistent histopathological,
immunohistochemical, biochemical and biological properties. However, since the
start of active surveillance in 2001, across Europe and elsewhere, approximately
67 cases with different biochemical characteristics have been identified by
Western blotting (WB). These cases fall into two categories; ‘H-type’ (H-BSE) or
‘L-type’ (L-BSE), based on the relatively heavy (H-BSE) or light (L-BSE) mass of
the unglycosylated band of the prion protein, as compared with WB against that
obtained from classical BSE (C-BSE) cases. Here we report the detection and
confirmation of the first four L-BSE cases by active surveillance in GB, two of
which were born after the reinforced feed ban of 1996 (BARB cases). These four
L-BSE cases were found in relatively old cattle (age range; 11–21 years old) and
the carcases did not enter the human food chain or animal feed chains.
Accepted November 19, 2012. Published Online First 18 December 2012
Veterinary Record2012;171:635 doi:10.1136/vr.e8541
News and Reports
BSE FSA to advise that BSE testing of healthy slaughter cattle can be
stopped
THE Food Standards Agency (FSA) is to advise the Government that the
testing of all healthy cattle aged over 72 months for BSE can be stopped. At its
meeting on December 11, the FSA's Board agreed that the testing of this cohort
of healthy cattle was no longer necessary, provided that other existing safety
controls …
stupid is, as stupid does, and some times, you just will never fix stupid
$$$
Thursday, December 20, 2012
OIE GROUP RECOMMENDS THAT SCRAPE PRION DISEASE BE DELISTED AND SAME OLD BSe
WITH BOVINE MAD COW DISEASE
snip...
IT is of my opinion, that the OIE and the USDA et al, are the soul reason,
and responsible parties, for Transmissible Spongiform Encephalopathy TSE prion
diseases, including typical and atypical BSE, typical and atypical Scrapie, and
all strains of CWD, and human TSE there from, spreading around the globe.
I have lost all confidence of this organization as a regulatory authority
on animal disease, and consider it nothing more than a National Trading
Brokerage for all strains of animal TSE, just to satisfy there commodity. AS i
said before, OIE should hang up there jock strap now, since it appears they will
buckle every time a country makes some political hay about trade protocol,
commodities and futures. IF they are not going to be science based, they should
do everyone a favor and dissolve there organization.
JUST because of low documented human body count with nvCJD and the long
incubation periods, the lack of sound science being replaced by political and
corporate science in relations with the fact that science has now linked some
sporadic CJD with atypical BSE and atypical scrapie, and the very real threat of
CWD being zoonosis, I believed the O.I.E. has failed terribly and again, I call
for this organization to be dissolved. ...
snip...see full text ;
Saturday, December 15, 2012
Bovine spongiform encephalopathy: the effect of oral exposure dose on
attack rate and incubation period in cattle -- an update 5 December 2012
Friday, November 30, 2012
PROPOSED DECISION TO STOP BSE TESTING OF HEALTHY CATTLE SLAUGHTERED FOR
HUMAN CONSUMPTION FSA 12/12/04 Open Board – 11 December 2012
Thursday, August 12, 2010
Seven main threats for the future linked to prions
First threat
The TSE road map defining the evolution of European policy for protection
against prion diseases is based on a certain numbers of hypotheses some of which
may turn out to be erroneous. In particular, a form of BSE (called atypical
Bovine Spongiform Encephalopathy), recently identified by systematic testing in
aged cattle without clinical signs, may be the origin of classical BSE and thus
potentially constitute a reservoir, which may be impossible to eradicate if a
sporadic origin is confirmed. ***Also, a link is suspected between atypical BSE
and some apparently sporadic cases of Creutzfeldt-Jakob disease in humans. These
atypical BSE cases constitute an unforeseen first threat that could sharply
modify the European approach to prion diseases.
Second threat
snip...
EFSA Journal 2011 The European Response to BSE: A Success Story
This is an interesting editorial about the Mad Cow Disease debacle, and
it's ramifications that will continue to play out for decades to come ;
Monday, October 10, 2011
EFSA Journal 2011 The European Response to BSE: A Success Story
snip...
EFSA and the European Centre for Disease Prevention and Control (ECDC)
recently delivered a scientific opinion on any possible epidemiological or
molecular association between TSEs in animals and humans (EFSA Panel on
Biological Hazards (BIOHAZ) and ECDC, 2011). This opinion confirmed Classical
BSE prions as the only TSE agents demonstrated to be zoonotic so far but the
possibility that a small proportion of human cases so far classified as
"sporadic" CJD are of zoonotic origin could not be excluded. Moreover,
transmission experiments to non-human primates suggest that some TSE agents in
addition to Classical BSE prions in cattle (namely L-type Atypical BSE,
Classical BSE in sheep, transmissible mink encephalopathy (TME) and chronic
wasting disease (CWD) agents) might have zoonotic potential.
snip...
see follow-up here about North America BSE Mad Cow TSE prion risk factors,
and the ever emerging strains of Transmissible Spongiform Encephalopathy in many
species here in the USA, including humans ;
Saturday, October 6, 2012
TRANSMISSION, DIFFERENTIATION, AND PATHOBIOLOGY OF TRANSMISSIBLE SPONGIFORM
ENCEPHALOPATHIES 2011 Annual Report
2011 Monday, September 26, 2011
L-BSE BASE prion and atypical sporadic CJD
Friday, November 23, 2012
sporadic Creutzfeldt-Jakob Disease update As at 5th November 2012 UK, USA,
AND CANADA
layperson
TSS
RIP MOM 12/14/97 confirmed hvCJD
posted by Terry S. Singeltary Sr. at
10:18 AM
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